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MK2-IN-1 hydrochloride
CAS No. 1314118-94-9
MK2-IN-1 hydrochloride( MK2 Inhibitor )
Catalog No. M11261 CAS No. 1314118-94-9
MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 176 | In Stock |
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| 50MG | 318 | In Stock |
|
| 100MG | 470 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK2-IN-1 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM.
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DescriptionMK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM; shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition; inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion; also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.
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In VitroWestern Blot Analysis Cell Line:46C mouse embryonic stem cells (mESCs) .Concentration:5 μM Incubation Time:0.5, 1, 2, 8 h Result:The Tfcp2l1 protein level gradually increased without a change in the Tfcp2l1 transcript level within 2 h.
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In Vivo——
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SynonymsMK2 Inhibitor
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PathwayMAPK/ERK Signaling
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TargetMAPKAPK2 (MK2)
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RecptorMK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1314118-94-9
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Formula Weight509.4269
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Molecular FormulaC27H26Cl2N4O2
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESO=C(C1=CC=C(C2=CC=C(Cl)C=C2)O1)N(C3=CC=C(N4CCNCC4)C=C3)CC5=NC=CC=C5.[H]Cl
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Chemical Name2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rao AU, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.
2. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.
3. Huang X, et al. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.
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